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getting his first start on the wing since returning from injury. Tom Marshall comes in at second five eighth and is joined in the midfield by Charlie Ngatai.
Chiefs: 15 Nanai Williams, 14 Sweeney, 13 Ngatai, 12 Marshall, 11 Lowe, 10 Anscombe, 9 Kerr Barlow; 1 Manu, 2 Harris, 3 Hohneck, 4 Filipo, 5 Retallick, 6 Latimer, 7 Cane, 8 Liam Messam (c).
In the five changes to the bench, Mahonri Schwalger moves to the reserves and is joined by Ben Tameifuna for the first time this season, while Mike Fitzgerald, Andrew Horrell and Bundee Aki are also among the replacements.
You can see all the action live on Sky Sports 3HD from 8.30am.
fortnight ago, with Warren Whiteley having made a full recovery from injury to captain the side at number eight.
"We know we are in control of our own destiny and this is a defining match for us," said Rennie, whose side go into the clash on the back of a 18 17 home defeat to the Crusaders and 41 23 loss on the road to the Brumbies.
Replacements: 16 Schwalger, 17 Mackintosh, 18 Tameifuna, 19 Symons, 20 Fitzgerald, 21 Weber, 22 Aki, 23 Horrell.
In the back line, Faf de Klerk has reclaimed his spot in the run on side, Elton Jantjies starts at fly half and Deon van Rensburg returns in the wing position, having recovered from his minor injury.
Chiefs coach Dave Rennie has made 14 changes to his squad, with nine of those changes in the starting XV.
Lions: 15 Botha, 14 van Rensburg, 13 Mapoe, 12 Watermeyer, 11 Skosan , 10 Jantjies, 9 de Klerk; 1 S van der Merwe, 2 Coetzee, 3 Redelinghuys, 4 Muller, 5 Mostert, 6 Kriel, 7 Minnie, 8 Whiteley (c).
Lions changesFor the Lions, head coach Johan Ackermann has made four changes to his starting XV.
Hooker Nathan Harris and prop Josh Hohneck get their first starts of the season, while Tanerau Latimer moves into the number six jersey in the forwards.
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Dwayne Sweeney starts on the right wing and Tim Nanai Williams moves from the wing back to full back.
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In the forwards, there is just one change to the team which went down 18 3 to the Stormers in Cape Philipp Plein Boots Glitter Town a Palladium Boots Baggy Leather Gusset
Barlow is the starting half back, with James Lowe Palladium Boots Unisex
On the bench, Armand van der Merwe will make his Super Rugby debut should he get a run out on Saturday. Jacques van Rooyen will also provide cover off the bench, having been called up from the Vodacom Cup squad.
Due to De Klerk and Jantjies earning starting positions, Ross Cronje and Marnitz Boshoff are the other changes amongst the replacements.
"We have boxed ourselves into a corner with recent results and now we need to come out fighting."
Philipp Plein Boots Glitter
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